Maduropeptin, a complex of new macromolecular antitumor antibiotics.
نویسندگان
چکیده
Maduropeptin, a complex of new macromolecular antitumor antibiotics, is a metabolite of Actinomadura madurae H710-49. The active components maduropeptins A1, A2 and B are acidic chromopeptides with MW of around 22,500 and composed of 14 types of amino acids and an unstable chromophore. The antibiotics are active in vitro against Gram-positive bacteria and highly cytotoxic to tumor cells. They produced significant prolongation of survival time of mice implanted with P388 leukemia and B16 melanoma.
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عنوان ژورنال:
- The Journal of antibiotics
دوره 44 4 شماره
صفحات -
تاریخ انتشار 1991